Copied partially from www.windowsitpro.com - InstantDoc ID 48249

You can find Delprof in the various Windows resource kits, or download from here
at http://brad.dinerman.com/techtips/delprof.msi.txt.  (Rename file as delprof.msi after download.)

usage:  DELPROF [/Q] [/I] [/P] [/R] [/C:\\<computername>] [/D:<days>]

        /Q      Quiet, no confirmation.
        /I      Ignore errors and continue deleting.
        /P      Prompts for confirmation before deleting each profile.
        /R      Delete roaming profile cache only
        /C      Remote computer name.


For example, the command 

Delprof.exe /I /Q /C:\\pc1 /D:90 

tells Delprof to delete all the profiles that haven't been used in the past 90 days
from the computer named PC1.
/I - switch tells Delprof to ignore errors.
/Q - switch tells the utility to delete profiles without confirmation.
The /Q switch is important to include if you plan to automate the deletion process.
When you don't include this switch, you must confirm that you want to delete each
profile before Delprof will delete it. 

To automate the deletion process, you can create a simple text file named computers.txt
that contains all the names of the computers in your network.
You need to put each name on a separate line. After you've created this file,
run the following For command from the command-shell window: 

For /f %a in (computers.txt) Do 
  Delprof.exe /I /Q /C:\\%a /D:90
  
Delprof will then delete all the profiles that haven't been used in the past 90 days
from the computers specified in the text file. 

Alternatively, you can place the For command in a batch file,
which you can then schedule to run periodically. Note that you must replace the two
occurrences of %a with %%a to use this command inside a batch file.
(When you use an iterator variable in a For command that you execute from a
command prompt, you use one percent sign. When you use an iterator variable in
a For command in a batch file, you must use a double percent sign.) 

— Apostolos Fotakelis